\n<\/p>\n
G\u00fcney Kore ve ABD\u2019den ara\u015ft\u0131rmac\u0131lar, ya\u015flanman\u0131n yaln\u0131zca bireysel h\u00fccre s\u00fcre\u00e7lerinden ibaret olmad\u0131\u011f\u0131n\u0131, kan yoluyla v\u00fccutta yay\u0131labilecek \u201cbula\u015f\u0131c\u0131\u201d bir mekanizma olabilece\u011fini ortaya koydu.<\/p>\n
Hakemli bilimsel dergi Metabolism’de yay\u0131nlanan \u00e7al\u0131\u015fmada, insan h\u00fccreleri ve fareler \u00fczerinde yap\u0131lan deneylerde, ya\u015fl\u0131 bireylerden al\u0131nan HMGB1 adl\u0131 DNA d\u00fczenleyici proteinin gen\u00e7 h\u00fccrelere enjekte edilmesiyle, bu h\u00fccrelerin h\u0131zla ya\u015flanma belirtileri g\u00f6stermeye ba\u015flad\u0131\u011f\u0131 bulundu.<\/p>\n
Normalde h\u00fccre \u00e7ekirde\u011finde bulunan HMGB1, DNA\u2019y\u0131 d\u00fczenleyen bir protein. Ancak h\u00fccre ya\u015flanmaya ba\u015flad\u0131\u011f\u0131nda veya strese girdi\u011finde \u00e7ekirdekten sal\u0131narak h\u00fccrenin b\u00f6l\u00fcnmeyi durdurdu\u011fu ve bozulmaya ba\u015flad\u0131\u011f\u0131 \u201csenesens\u201d s\u00fcrecini tetikliyor.<\/p>\n
Ara\u015ft\u0131rma ekibine g\u00f6re HMGB1\u2019in iki formu var. \u0130ndirgenmi\u015f (reduced) form, oksijen azl\u0131\u011f\u0131nda ortaya \u00e7\u0131k\u0131yor ve sa\u011fl\u0131kl\u0131 h\u00fccrelere ba\u011fland\u0131\u011f\u0131nda onlar\u0131 da ya\u015fland\u0131r\u0131yor. Oksitlenmi\u015f (oxidized) form ise ayn\u0131 etkiyi g\u00f6stermiyor; h\u00fccreler normal \u015fekilde b\u00f6l\u00fcnmeye devam ediyor.<\/p>\n
\u00c7al\u0131\u015fmada, insan b\u00f6brek, akci\u011fer, kas ve cilt h\u00fccreleri indirgenmi\u015f HMGB1\u2019e maruz b\u0131rak\u0131ld\u0131\u011f\u0131nda, bu h\u00fccreler h\u0131zla ya\u015flanma belirtileri (senesens) ve iltihap molek\u00fclleri salg\u0131lamaya ba\u015flad\u0131. Oksitlenmi\u015f formda ise h\u00fccreler sa\u011fl\u0131kl\u0131 kald\u0131.<\/p>\n
Fare deneylerinde de benzer sonu\u00e7lar elde edildi. Gen\u00e7, sa\u011fl\u0131kl\u0131 farelere indirgenmi\u015f HMGB1 enjekte edildi\u011finde, sadece bir hafta i\u00e7inde erken ya\u015flanma belirtileri g\u00f6zlendi.<\/p>\n
70-80 ya\u015f aral\u0131\u011f\u0131ndaki yeti\u015fkinlerden al\u0131nan kan \u00f6rneklerinde indirgenmi\u015f HMGB1 seviyesinin, 40\u2019l\u0131 ya\u015flardaki bireylere k\u0131yasla \u00e7ok daha y\u00fcksek oldu\u011fu belirlendi. Ayn\u0131 durum ya\u015fl\u0131 laboratuvar farelerinde de g\u00f6r\u00fcld\u00fc.<\/p>\n
Kore \u00dcniversitesi\u2019nden ara\u015ft\u0131rmac\u0131 Ok Hee Jeon, \u201cBu \u00e7al\u0131\u015fma, ya\u015flanma sinyallerinin yaln\u0131zca bireysel h\u00fccrelerle s\u0131n\u0131rl\u0131 olmad\u0131\u011f\u0131n\u0131, kan yoluyla sistem genelinde iletilebilece\u011fini g\u00f6steriyor\u201d dedi.<\/p>\n
Bu bulgular, ya\u015flanman\u0131n h\u00fccreden h\u00fccreye adeta \u201cmikroskobik vampirler\u201d gibi yay\u0131ld\u0131\u011f\u0131n\u0131 ortaya koyarken, ileride ya\u015flanmay\u0131 yava\u015flatmaya y\u00f6nelik tedaviler i\u00e7in de yeni bir hedef sunuyor.<\/p>\n
Ara\u015ft\u0131rmac\u0131lar, \u00e7al\u0131\u015fman\u0131n hen\u00fcz erken a\u015famada oldu\u011funu ancak ya\u015flanma mekanizmalar\u0131n\u0131 anlamada kritik bir ad\u0131m niteli\u011fi ta\u015f\u0131d\u0131\u011f\u0131n\u0131 belirtiyor.<\/p>\n<\/div>\n