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Alzheimer<\/a> hastal\u0131\u011f\u0131n\u0131 tedavi etmek i\u00e7in yap\u0131lan \u00e7al\u0131\u015fmalar devam ederken, pazartesi g\u00fcn\u00fc yay\u0131nlanan bir ara\u015ft\u0131rma hastal\u0131\u011f\u0131n tedavisinin gelece\u011finin kanser ila\u00e7lar\u0131nda olabilece\u011fini ortaya koydu. \u0130ki kanser ilac\u0131n\u0131n hen\u00fcz tedavisi bulunamam\u0131\u015f bir hastal\u0131k olan Alzheimer<\/a>‘\u0131n semptomlar\u0131n\u0131 yava\u015flatma ya da tersine \u00e7evirme etkisi g\u00f6sterdi\u011fi g\u00f6r\u00fcld\u00fc.\u00a0<\/p>\n ABD\u2019deki G\u0131da ve \u0130la\u00e7 Dairesi, (FDA) halihaz\u0131rda Alzheimer\u2019\u0131n erken d\u00f6nemindeki ilerleyi\u015fini durdurmak i\u00e7in iki ilac\u0131n kullan\u0131m\u0131na onay vermi\u015f durumda. Bu iki ila\u00e7 Leqembi ve Kisunla. Fakat bilim insanlar\u0131na g\u00f6re bu ila\u00e7lar\u0131n faydalar\u0131 da s\u0131n\u0131rl\u0131. <\/p>\n Baz\u0131 ila\u00e7 \u015firketleri bu s\u00fcre\u00e7te ba\u015far\u0131s\u0131z denemeler sebebiyle Alzheimer\u2019a kar\u015f\u0131 ila\u00e7 geli\u015ftirme programlar\u0131n\u0131 bir kenara b\u0131rak\u0131rken, di\u011ferleri ise halihaz\u0131rda mevcut olan ila\u00e7lar\u0131n Alzheimer\u2019a kar\u015f\u0131 kullan\u0131l\u0131p kullan\u0131lamayaca\u011f\u0131n\u0131 mercek alt\u0131na al\u0131yor. ABD\u2019deki San Francisco Kaliforniya \u00dcniversitesi\u2019ndeki ara\u015ft\u0131rmac\u0131lar da buradan hareketle bir ara\u015ft\u0131rma yapt\u0131.\u00a0<\/p>\n B\u0130R\u0130 KOLON VE AKC\u0130\u011eER, D\u0130\u011eER\u0130 MEME KANSER\u0130 \u0130LACI<\/strong><\/p>\n Bilim insanlar\u0131, bu \u00e7al\u0131\u015fma kapsam\u0131nda bin 300\u2019den fazla ilac\u0131n oldu\u011fu veritaban\u0131n\u0131 inceledi. Bu veritaban\u0131nda antipsikotik, antibiyotik, mantar kar\u015f\u0131t\u0131 ve kemoterapi ila\u00e7lar\u0131 da bulunuyordu. Ara\u015ft\u0131rmac\u0131lar, ard\u0131ndan bu ila\u00e7lar\u0131n gen ifadesini nas\u0131l etkiledi\u011fini ara\u015ft\u0131rd\u0131.\u00a0<\/p>\n 21 Temmuz\u2019da Cell dergisinde yay\u0131nlanan ara\u015ft\u0131rmaya g\u00f6re, iki kanser ilac\u0131 hastalardaki Alzheimer riskini azaltmak i\u00e7in en iyi adaylar olarak \u00f6ne \u00e7\u0131kt\u0131. Bu iki ila\u00e7 bir araya getirildi\u011finde deney farelerindeki Alzheimer belirtilerini ya yava\u015flatt\u0131 ya da tersine \u00e7evirdi. \u0130la\u00e7lardan birinin normalde meme kanseri i\u00e7in, di\u011fer ilac\u0131n ise kolon ve akci\u011fer kanseri i\u00e7in kullan\u0131ld\u0131\u011f\u0131 ifade edildi.\u00a0<\/p>\n Ara\u015ft\u0131rma kapsam\u0131nda mercek alt\u0131na al\u0131nan ila\u00e7lardan sadece 90\u2019dan az\u0131n\u0131n insanlar\u0131n beyin h\u00fccrelerindeki Alzheimer ile ba\u011flant\u0131l\u0131 genlerin ifadesini tersine \u00e7evirdi\u011fi g\u00f6r\u00fcld\u00fc. Elektronik t\u0131p kay\u0131tlar\u0131na g\u00f6re, \u00f6zellikle be\u015f ilac\u0131n da ger\u00e7ek hastalardaki Alzheimer riskini azaltt\u0131\u011f\u0131 g\u00f6r\u00fcld\u00fc. Ara\u015ft\u0131rmac\u0131lar, bu ila\u00e7lar aras\u0131ndan FDA taraf\u0131ndan onaylanm\u0131\u015f iki kanser ilac\u0131n\u0131 se\u00e7erek fareler \u00fczerinde denedi.\u00a0<\/p>\n B\u0130RL\u0130KTE DAHA G\u00dc\u00c7L\u00dcLER<\/strong><\/p>\n Ara\u015ft\u0131rman\u0131n yazarlar\u0131ndan UCSF Bakar Bilgisayarl\u0131 Sa\u011fl\u0131k Bilimleri Enstit\u00fcs\u00fc Ge\u00e7ici Direkt\u00f6r\u00fc Marina Sirota, yapt\u0131klar\u0131 ara\u015ft\u0131rmadan kanser ila\u00e7lar\u0131n\u0131n \u00e7\u0131kmas\u0131n\u0131 beklemediklerini anlatt\u0131.\u00a0<\/p>\n Ara\u015ft\u0131rmada payla\u015f\u0131lan bilgilere g\u00f6re, meme kanseri ilac\u0131 letrozole sinir h\u00fccrelerindeki gen ifadesini de\u011fi\u015ftirirken, kolon ve akci\u011fer kanseri ilac\u0131 irinotecan sinir sistemini destekleyen gliyal h\u00fccrelerdeki gen ifadesini de\u011fi\u015ftirdi. Alzheimer, sinir h\u00fccrelerini yok edebiliyor ve gliyal h\u00fccrelerin artmas\u0131na yol a\u00e7abiliyor, bu da beyinde inflamasyona sebep oluyor.\u00a0<\/p>\n Ara\u015ft\u0131rmac\u0131lar, iki ilac\u0131 birlikte kullan\u0131ld\u0131klar\u0131nda, ya\u015fland\u0131k\u00e7a Alzheimer semptomlar\u0131 g\u00f6steren farelerdeki beyin dejenerasyonunun tersine d\u00f6nd\u00fc\u011f\u00fcn\u00fc ve haf\u0131zalar\u0131n\u0131n iyile\u015fti\u011fini g\u00f6rd\u00fc.\u00a0<\/p>\n Farelerde elde edilen sonu\u00e7lar her zaman insanlarda ayn\u0131 sonu\u00e7lar\u0131 vermedi\u011finden ara\u015ft\u0131rmac\u0131lar \u015fimdi ilac\u0131 Alzheimer hastalar\u0131 \u00fczerinde denemeyi umuyor.<\/p>\n<\/div>\n